Intermediate dehydrogenase-oxidase form of xanthine oxidoreductase in rat liver
نویسندگان
چکیده
منابع مشابه
Unique amino acids cluster for switching from the dehydrogenase to oxidase form of xanthine oxidoreductase.
In mammals, xanthine oxidoreductase is synthesized as a dehydrogenase (XDH) but can be readily converted to its oxidase form (XO) either by proteolysis or modification of cysteine residues. The crystal structures of bovine milk XDH and XO demonstrated that atoms in the highly charged active-site loop (Gln-423-Lys-433) around the FAD cofactor underwent large dislocations during the conversion, b...
متن کاملP-91: Vitamin E and Selenium Supplementation Affects Aldehyde Oxidase, Xanthine Dehydrogenase/Oxidase Activities In Diabetic Rat Ovaries
Background Any factor like diabetes that changes the oxidant/antioxidant balance in favor of oxidants could possibly disrupt the physiologic function of ovaries. So, we have investigated the effect of vitamin E and Se supplements on antioxidant defense in ovaries of diabetic rats with focus on Xanthine dehydrogenase/oxidase (XDH/XO) and Aldehyde oxidase (AO) activities. MaterialsAndMethods This...
متن کاملIdentification of the rat xanthine dehydrogenase/oxidase promoter.
Inflammation and ischemia--reperfusion tissue injury are important pathophysiologic processes with a wide spectrum of clinical presentations; the enzyme xanthine dehydrogenase/oxidase (XDH/XO) is thought to play a key role in ischemia--reperfusion injury. Recent studies have shown the transcriptional regulation of XDH/XO by cytokines (Dupont et al., 1992, J. Clin. Invest. 89, 197-202). In the p...
متن کاملSynthesis of xanthine oxidase by rat liver slices in vitro.
The influence of dietary protein on the activity of rat liver xanthine oxidase has been studied by several workers (l-5) and would point to a relationship between the availability of amino acids and the activity of liver xanthine oxidase (2). It has been demonstrated that the loss of liver xanthine oxidase activity in the rat greatly exceeds the loss of liver protein during acute inanition (l),...
متن کاملPhosphorylation of xanthine dehydrogenase/oxidase in hypoxia.
The enzyme xanthine oxidase (XO) has been implicated in the pathogenesis of several disease processes, such as ischemia-reperfusion injury, because of its ability to generate reactive oxygen species. The expression of XO and its precursor xanthine dehydrogenase (XDH) is regulated at pre- and posttranslational levels by agents such as lipopolysaccharide and hypoxia. Posttranslational modificatio...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1979
ISSN: 0264-6021
DOI: 10.1042/bj1810177